The Developmental Origins of Health and Disease (DOHaD) concept describes how maternal and environmental factors during a child's life, right from conception, can affect that child's growth and development.
The DOHaD Consortium exists to promote inter-disciplinary research in order to prevent the rising global burden of non-communicable diseases (NCDs). The Consortium seeks to understand and characterise 'pathways of risk' on multiple levels ranging from a societal level to a molecular level. Based at The University of Western Australia (UWA), the DOHaD Consortium brings together a broad range of world-class experts investigating the 'early life origins of disease' across multiple disciplines and fields of medicine. All groups bring their own national and international collaborators generating links to an enormous global network of researchers investigating early life origins and prevention of NCDs.
UWA is also a prominent member of the World Universities Network (WUN), which established the 'WUN Early Life Opportunities for the Prevention of NCD in Developing Countries' as a new Global Challenge in 2011. Members of the DOHaD Consortium representing UWA played an active role in the development of the Shanghai Declaration promoting the importance of early life interventions in the prevention of NCDs, and continue to interact through this important forum. Focused research networks are also being developed though WUN (and beyond) through the specific thematic research clusters which are geared around particular NCD challenges.
All modern diseases are associated with modern lifestyle changes, suggesting common risk factors for many NCDs. These risks include unhealthy dietary patterns, reduced physical activity, altered patterns of microbial exposure, tobacco smoking, harmful use of alcohol, and other environmental pollutants.
Prevention is the ultimate approach to reducing the burden of NCDs. The greatest potential for success lies in early life and there is already substantial evidence that initiatives to promote a 'healthy start to life' can reduce the risk of both early and later NCDs with wide social and economic benefits. The early environment (pre-pregnancy and during early childhood) can modify physiological, structural, immune, metabolic, and behavioural response patterns to influence disease susceptibility.